IL16 and androgen insensitivity syndrome: Preclinical studies showed that IL-1β and IL-16 played pro-inflammatory roles after AIS, whereas IL-10, IL-2, and IL-2Rα played anti-inflammatory effects [13], and prognostic significance of CD40L, IL-1β, IL-10, IL-16, IL-2, IL-5, IL-2Rα, and MMP1had been implicated in clinical studies.