By integrating the genetics and nasopharyngeal airway metabolomics data from a multicenter, prospective cohort study of infants hospitalized for bronchiolitis, we identified genetically driven metabolites (e.g., 1,2-dioleoyl-GPG, sphingomyelin) associated with asthma development and genetic loci associated with both these metabolites and asthma susceptibility genes (e.g., ADORA1, MUC16). Here, MUC16 is linked to asthma.