IRF7 and asthma: The pathway analysis showed the biological importance of these loci with significant pathways (FDR<0.05; Figure S2), which are relevant to both bronchiolitis and asthma development—e.g., interferon-α/β (29), tumor necrosis factor receptor-associated factor 6 (TRAF6) mediated interferon regulatory factor 7 (IRF7) activation pathways (30).