Markers of microangiopathy including decreased levels of haptoglobin (52), elevated levels of LDH (15, 53), and scores that use laboratory values of microangiopathy, including BATAP (bilirubin, age, thrombocytopenia, anemia, proteinuria) (54) TMA index (LDH/platelets), and an EASIX score (55), all portended a poor prognosis. The gene discussed is HP; the disease is anemia.