TP53 was significantly more prevalent in the Chinese UTUC cohort compared to the MSKCC-UTCC cohort; on the contrary FGFR3, KDM6A, and KMT2C were more frequently altered in the MSKCC-UTUC cohort (Figure 8A, Supplementary Table 7). This evidence concerns the gene KMT2C and renal pelvis/ureter urothelial carcinoma.