(4) Glycogen synthase kinase-3β (GSK-3β): Cerebral ischemia-induced dephosphorylation and activation of GSK-3β reduces cAMP response element-binding protein (CREB) activity while enhancing NF-κB signaling to initiate pro-inflammatory capacity (137, 138). The gene discussed is GSK3B; the disease is Cerebral ischemia.