APOE and fatty liver disease: Experimental evidence demonstrates that 5-LOX expression is increased in several rodent models of liver disease, including liver fibrosis induced by CCl4 and MCD diet (Pu et al., 2021), acetaminophen-induced liver injury (Pu et al., 2016), diethyl nitrosamine (DEN)-induced HCC (Xu et al., 2011), HFD-induced NAFLD/NASH (Ma et al., 2017), and hepatic steatosis due to ApoE deficiency (Martinez-Clemente et al., 2010).