In the liver cancer model where PTEN loss drives steatosis and cancer (Stiles et al., 2004; He et al., 2016; Jia et al., 2017; Chen et al., 2021b), supplementation with a n-3 PUF, EPA, significantly attenuates both NASH and cancer development (Ishii et al., 2009). Here, PTEN is linked to cancer.