Thus, it exhibits thermoregulatory properties (Criterion-i), it is expressed in a key temperature-sensing organ, the anterior preoptic nucleus (Yano et al., 2004) (Criterion-ii), and it has been linked to a genetic disorder of thermoregulation (infantile febrile convulsions) in human cases of ADH (review: (Egbuna and Brown, 2008)) (Criterion-iii). Here, AVP is linked to hereditary disease.