CASR and Febrile seizure (within the age range of 3 months to 6 years): It is not known, however, whether the CaSR might also sense and respond to changes in temperature in the pathophysiological range as suggested by its expression in anterior preoptic neurons of the hypothalamus (Yano et al., 2004) and by the observation that activating mutations of the CaSR in type-I Autosomal Dominant Hypocalcemia (ADH) are associated with childhood febrile convulsions (Papadimitriou et al., 2001).