CASR and hereditary disease: Expression of the CaSR in thermoregulatory organs of the hypothalamus, observations that Ca2+o negatively modulates core body temperature together with the firing rates of thermoregulatory neurons, the existence of interactions between Ca2+o and the CaSR on the behavior of thermoregulatory ion channels, and the recognised impact of genetic disorders of calcium metabolism and/or the CaSR on thermoregulation and CNS function are all consistent with the hypothesis that the CaSR modulates thermal regulation in vivo.