The phenotype in the Myh6-McmTam:DspF/F mouse model resembles the phenotype of DSP-related cardiomyopathy, which is characterized by the prominence of cell death, inflammation, myocardial fibrosis, left-dominant or biventricular cardiomyopathy, and progressive heart failure[16,18–20]. Here, DSP is linked to Myocardial fibrosis.