DSP and Microcephaly - facio-cardio-skeletal syndrome, Hadziselimovic type: Consequently, there is no generalized genotype-phenotype correlation; suffice it to state that the homozygous deletion mutations in the JUP and DSP genes cause cardiocutaneous syndromes, including the Naxos disease, which are characterized by ACM, woolly hair, and keratosis[13–15].