Moreover, non-survivors experienced a higher incidence of comorbidities including prior myocardial infarction, atrial fibrillation, COPD, and malignant tumors, as well as abnormal conditions including lower LVEF, proteinuria, extremity edema, infection, higher blood glucose, electrolyte disturbance, lower blood pressure, lower hemoglobin and higher cTnI. The gene discussed is TNNI3; the disease is chronic obstructive pulmonary disease.