Significant variables (baseline eGFR, loop diuretics, atrial fibrillation, malignant tumor, proteinuria, glucose, calcium, and hemoglobin) from univariate logistic regression analyses and retained adjustors (NT-proBNP levels and AKI stages) were analyzed in multivariate models (Supplementary Table 4) as covariates. The gene discussed is NPPB; the disease is acute kidney injury.