This study preliminarily indicated that the citalopram would show a benefit in LVEF (MD: 2.42, 95% CI: 0.51 to 4.33, p = 0.01) and NT-proBNP (MD: −537.78, 95% CI: −718.03 to −357.54, p < 0.0001) associated with people of elderly chronic HF combined with depression. This evidence concerns the gene NPPB and major depressive disorder.