Our current work concentrates on constructing and comparing BNs centered around both JAK-STATs (as well as pSMAD (phosphorylated Suppressor of Mothers against Decapentaplegic) 2–3) and cell surface receptors in healthy donors and breast cancer patients and propagating probabilistic inference within the networks, with the goal to demonstrate that changes in the (relatively small number of) pSTATs lead to the more consequential downstream events. Here, CD177 is linked to breast carcinoma.