NFE2L3 and malignant colon neoplasm: GSEA results using our previous DNA microarray dataset of human colon cancer cells, HCT116-siRNA-mediated NRF3 knockdown (HCT116-siNRF3), and control (HCT116-siCtrl) showed that NRF3 expression was positively correlated with the “mTORC1 signaling” gene set (Figures 1A and 1B).