CD274 and neoplasm: In cohort 1, SECTM1 and PD-L1 were highly expressed in tumor tissues from responders and positively correlated with each other (Figures 6C, 6D, and S11A), and the predictive value of SECTM1 (AUC = 0.769) was higher than that of PD-L1 (AUC = 0.718) (Figure S11B).