In summary, the new genomic and epigenomic characterization of MPNST cell lines provided in this work uncovered the misidentification of the commonly used NF1-related T265 MPNST cell line and, in addition, compiled multiple pieces of evidence to question the identity of the three sporadic MPNST cell lines analyzed here, proposing alternative identities for all of them: a melanoma for STS-26T; a desmoplastic melanoma for the HS-Sch-2 cell line; and an epithelioid inflammatory myofibroblastic sarcoma for the HS-PSS. Here, NF1 is linked to malignant peripheral nerve sheath tumor.