The combination of positive staining for SOX10 and S100B and negative staining for Melan-A is characteristic of desmoplastic melanoma,47 which also commonly exhibits the complete inactivation of NF1 and CDKN2A,48,49 neurotropism and nerve infiltration,50,51 the latter described in the original publication of this cell line.52 The gene discussed is CDKN2A; the disease is desmoplastic melanoma.