Finally, HS-PSS also showed a WT status for PRC2 genes, was assigned to the provisional and not fully characterized “MPNST-like sarcoma” methylation group, was positive for SOX10, contained an almost unaltered genome proximal to 2n but harbored a translocation generating the fusion gene EML4-ALK. The gene discussed is ALK; the disease is malignant peripheral nerve sheath tumor.