Taking together our compiled evidence, in our opinion, the original diagnosis of a “malignant schwannoma”43 if made today would probably be “melanoma.” In this regard, it would be interesting to further analyze MPNSTs with BRAF V600E mutations described in the literature44,45,46 using additional tools like mutation frequencies and signatures, methylome classifier, and cell identity marker expression. This evidence concerns the gene BRAF and malignant peripheral nerve sheath tumor.