SOX10 and desmoplastic melanoma: The combination of positive staining for SOX10 and S100B and negative staining for Melan-A is characteristic of desmoplastic melanoma,47 which also commonly exhibits the complete inactivation of NF1 and CDKN2A,48,49 neurotropism and nerve infiltration,50,51 the latter described in the original publication of this cell line.52