Therefore, according to the results of CytoNCA, a total of 9 key nodes were further screened out, which were considered to be the core targets for A. officinarum against T2DM, including AKT1 (AKT serine/threonine kinase 1), STAT3 (signal transducer and activator of transcription 3), TNF (tumor necrosis factor), TP53 (tumor protein P53), SRC (SRC proto-oncogene, non-receptor tyrosine kinase), EGFR (epidermal growth factor receptor), ALB (albumin), MAPK1 (mitogen-activated protein kinase 1), and PPARG (peroxisome proliferator-activated receptor gamma). The gene discussed is TP53; the disease is type 2 diabetes mellitus.