The following causes may be responsible for the development of resistance, including lacking PD-1 receptors, lacking CD8+ T-cells related to endogenously activated WNT-β-catenin pathway within melanoma cells, genetic mutations, tumor antigen presentation and mutation, dynamic alterations in tumor immune microenvironment (TIME), and epigenetic alterations of some critical cancer proteins [9]. Here, CD8A is linked to neoplasm.