However, four genes, i.e., HPDL, GRIPAP1, GBP2, and TRIM34, have been reported to exhibit prognostic significance with respect to melanoma for the first time, while HAPLN3, CCL8, FCGR2A, and IFITM1 [43–46] have been reported to relate with the initiation and immune microenvironment of cutaneous melanoma. This evidence concerns the gene HPDL and cutaneous melanoma.