Guanylate binding protein 2 (GBP2), a member of the GTPase family, is crucial to host immunity against pathogens and has been demonstrated as a potential immunotherapeutic target for multiple “cold” tumor, such as proficient-mismatch-repair or microsatellite stability (pMMR/MSS) colorectal cancer [38]. The gene discussed is GBP2; the disease is colorectal cancer.