In terms of genetics, during the study of autoimmune pancreatitis, it was found that human leukocyte differentiation antigen made patients more likely to have IgG4-RD, and the expression of nonaspartate DQBI57 was closely related to the recurrence of autoimmune pancreatitis [22, 23]. Here, CD1E is linked to immunoglobulin G4-related sclerosing disease.