CA2 and infection: Studies in microbial infections have found that carbonic anhydrase II and ubiquitin-protein ligase in pancreatic acinar epithelial cells of the human body are homologous to α-carbonic anhydrase and plasmin-binding proteins of Helicobacter pylori, respectively [20, 21], and the genetic population is likely to induce abnormal autoimmune responses in the human body after infection with Helicobacter pylori, resulting in inflammatory reactions and tissue damage.