NGS has allowed for the analysis of extremely large DLBCL samples in order to differentiate impactful pathogenetic sequences from those that do not significantly alter disease course, as well as provide a meaningful way of typing cells more accurately than the current standard (ABC/GCB grouping based off variable immunochemistry) (Mansouri et al., 2022). Here, ABCB6 is linked to diffuse large B-cell lymphoma.