Inactivation of negative regulators of RELB is also seen in up to 15% of cases, specifically inactivation of the TRAF2/3 complex, and overactivation of RELB is thought to indicate dismal outcome after immunochemotherapy because RELB confers DLBCL cell resistance to DNA damage induced apoptosis, preventing genotoxic agent doxorubicin from having the desired effect (Schmitz et al., 2018; Eluard et al., 2022). This evidence concerns the gene RELB and diffuse large B-cell lymphoma.