EZH2 and diffuse large B-cell lymphoma: EZH2 mutation alone is not enough to create an environment conducive to the development of DLBCL, however in mice it has been shown that EZH2 mutation coupled with overexpression of BCL2 may be able to propagate the development of DLBCL (Cattoretti et al., 2005; Miao et al., 2019).