In both incidental LB disease (iLBD) and symptomatic stages of PD, the up-regulation of ApoE and LRP1 in the melanized neurons of the substantia nigra (SN) is associated with alterations in lipoprotein homeostasis, presumably as an early event in the process of PD development [110], possibly in an attempt to prevent aggregation of α-Syn. Here, APOE is linked to Parkinson disease.