The patatin-like phospholipase domain-containing protein 3 gene (PNPLA3), Membrane bound O-acyltransferase domain containing 7 gene (MBOAT7), transmembrane 6 superfamily member 2 gene (TM6SF2), and glucokinase regulator gene (GCKR) have been the most recognized genes involved in the pathogenesis of fatty liver diseases (9, 10). The gene discussed is TM6SF2; the disease is fatty liver disease.