MTOR and rheumatoid arthritis: Transcriptomics analysis of RNA-Seq on synovial tissue biopsies from healthy donors (n = 28) and RA patients (n = 151) (GEO database GSE89408) (29) revealed enrichment in several key components in the mTOR pathway (Figures 1A, B) with known and predicted interactions of dysregulated genes depicted in Figure 1C.