Endostatin, PIGF, thrombospondin-2, VEGF-R3, angiopoietin-1, PDGF-AA, MMP-9, CA-125, vWF, FGF-acidic, and KL-6 biomarkers were not able to discriminate between LAM patients and OCLD patients or healthy volunteers (Table 2 and Supplementary Figures 1, 2). This evidence concerns the gene MUC16 and lymphangioleiomyomatosis.