At the opposite, the EGFR Q787Q synonymous polymorphism appears to confer greater sensitivity to EGFR tyrosine kinase inhibitors (TKIs), due to a long noncoding RNA-mediated mechanisms, and has been reported in 17% of HPV-related and 32% of HPV-unrelated oropharyngeal HNSCC patients (24). The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.