In particular, nuclear EGFR appears associated with induced chemo-radiation resistance, since its level was found to increase following in vitro irradiation, cisplatin exposure, or treatment of HNSCC cells with Cetuximab or with the EGFR TKIs Erlotinib and Lapatinib (12, 96–98). The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.