TARDBP and nervous system disorder: ,3,4,5 Autophagy and the ubiquitin-proteasome system are important for TDP-43 clearance,6 and the induction of autophagy was shown to enhance TDP-43 degradation, leading to the suppression of TDP-43 aggregation and the alleviation of neurological disease phenotypes in a TDP-43 transgenic mouse,7 and in induced pluripotent stem cell-derived neurons with a pathogenic TDP-43 mutation.8