In patients with plaque psoriasis, a chronic, immune-related disease, the secretory function of the PG and SMG is lost and salivary amylase activity and total protein concentration is decreased, meanwhile TNF-1, IL-2, and INF-γ level are higher with lower IL-10 (89), salivary total oxidant status and oxidative status index may be potential diagnostic biomarkers for plaque psoriasis (90). This evidence concerns the gene IL2 and psoriasis vulgaris.