Nevertheless, as ALP values normalization may be associated to hypercalcemia and hypercalciuria in case of overtreatment of some forms of rickets, we also recommend to evaluate other parameters, e.g. PTH, vitamin 25OHD, 1,25(OH)2D3, calcium and phosphorus levels both in blood and urine, in association to auxological and radiological evaluations, in the follow up of patients with rickets. This evidence concerns the gene PTH and Hypercalciuria.