We next checked the gene expression of AgRP and Pomc. AgRP mRNA expression was not significantly downregulated in HF-HF (p = 0.3, compared to C-C), but was upregulated in HF-C (p=0.0406) and HF-CR group (p <0.01) compared to C-C (ANOVA, F (3, 33) = 11.83, p < 0.0001, Figure 2C). The gene discussed is AGRP; the disease is hydrops fetalis.