POMC and hydrops fetalis: To determine the dynamics of the energy-balance related transcripts that are commonly expressed in the ARC, we next checked the gene expression of AgRP and Pomc. AgRP mRNA expression was downregulated in HF-HF (p < 0.05, compared to C-C), incrementally increased in HF-C and significantly upregulated in the HF-CR group (p <0.0001) (ANOVA, F (3, 63) = 8.1, p < 0.0001, Figure 1F).