Pomc, which is cleaved to α-MSH, a satiety hormone that counterbalances the effects of AgRP, was non-significantly upregulated in obese rats but was significantly downregulated in the HF-CR group (compared to HF-HF, p< 0.001) (ANOVA: F (3, 50) = 5.4, p <0.01; Figure 1G). This evidence concerns the gene STAMBP and hydrops fetalis.