CD8A and type 1 diabetes mellitus: An increased risk of T1D progression was associated with the presence of altered gene expression, immune markers including regulatory T cell dysfunction and higher short-lived effector CD8<sup>+</sup> T cells in progressors.<h4>Discussion</h4>Several circulating biomarkers are dysregulated before T1D diagnosis and may be useful in predicting either the risk or rate of progression to T1D.