IL2 and eye infection: However, ocular infection with this recombinant HSV-1 that constitutively overexpresses cytokines demonstrated that HSV-IL-2 (but not HSV-IL-4, HSV-IFN-γ, HSV-IL-12p35 or HSV-IL-12p40) elicited optic neuropathy as determined by changes in visual-evoked cortical potentials (VECPs) and typical pathologic changes in the optic nerve and CNS (20–23).