STRA6, IGFL2, USP2 and CASP14 are associated with the prognosis of other cancers, including hepatocellular carcinoma, bladder cancer, gastric cancer and clear cell renal cell carcinoma (42–48).The overexpression of CFTR suppressed the proliferation and migration/invasion of ESCC cells and was associated with a good patient prognosis (49). The gene discussed is IGFL2; the disease is cancer.