In our study, we observed a decreased frequency of the C1/C2 heterozygotic genotype and increased frequencies of both C1/C1 and C2/C2 genotypes in NSCLC, suggestive of the presentation of a wider repertoire of tumor antigens to T cells by a larger panel of HLA-C molecules, or wider KIR repertoire of NK cells maturing in the C1/C2 context. The gene discussed is KIR3DL1; the disease is non-small cell lung carcinoma.