The microbiota(such as Haemophilus influenzae, Morganella morganii, and Escherichia fergusonii) may also modulate tumor metastasis by altering multiple cellular signaling pathways and participate in tumor angiogenesis through vascular endothelial growth factor (VEGF), endothelial cells (EC), inflammatory factors and inflammatory cells (28). Here, VEGFA is linked to neoplasm.