The effects of EtOH and CRS combination on the E-Cadherin and β-catenin distribution appears to be more severe in wild-type mice, and such an effect of EtOH and CRS was absent in Trpv6-/- mice; confirmed by densitometry of β-catenin at the epithelial junctions (Supplementary Figure S4B). The gene discussed is TRPV6; the disease is congenital rubella syndrome.