SLC1A2 and central nervous system cancer: Thus, in brain cancer, neoplastic transformation of glioma and glioblastoma cells decreases EAAT-mediated glutamate uptake (EAAT1 and EAAT2), with an increase in cystine efflux by the xCT, leading to the increase in synaptic glutamate concentration and the neurodegeneration of the surrounding neuronal cell due to the high concentration of glutamate (39).