In glioma, the silence of mGluR1 by a specific targeted small interfering RNA (siRNA) or the inhibition by an allosteric selective antagonist BAY36-7620 (50 μM) and a non-selective antagonist Riluzole (50 μM) of mGluR1, induced the apoptosis of U87 glioma cells. The gene discussed is GRM1; the disease is central nervous system cancer.