NFKB1 and metabolic dysfunction-associated steatohepatitis: For example, the active ingredient Poria cocos polysaccharides (PCP) downregulates the nuclear factor kappa-B (NF-Kb)/CCL3/CCR1 axis by regulating gut microbes to prevent nonalcoholic steatohepatitis (NASH) (18); Si Miao Formula (19) and Ophiopogon polysaccharide MDG-1 can alleviate NAFLD by inhibiting the gut microbiota and gut-liver axis (20); and oridonin has also been proven to reduce liver injury by altering gut microbiota and promoting the hepatic urea cycle (21).