Since the weight of transplanted mice started to decrease soon after the infusion of hMNCs as an early sign of GvHD (5% weight decrease in 3 days), recipients were treated with a single dose of either 1x106 WT-MSCs or CXCR4-IL10-MSCs at 3 days post-hMNC transplantation. The gene discussed is IL10; the disease is graft versus host disease.