When levels of soluble factors involve in the immunosuppression properties of MSCs, such as IL-10, TFGb and IL-6, were analyzed, a significant increase was observed in WT-MSC treated mice with respect the GvHD control, although this difference was more marked in CXCR4-IL10-MSCs treated mice (31–33). Here, CXCR4 is linked to graft versus host disease.