In addition, we performed GSVA analysis on three PRGclusters and found that PRGcluster A was highly expressed in apoptosis, linoleic acid metabolism, and P53 signaling pathway; PRGcluster B was highly expressed in infection, immunity, pyroptosis, and various tumors; and PRGcluster C was up-regulated in olfactory transduction and glycine serine and threonine metabolism (Figure 3F). Here, TP53 is linked to infection.