The top three Meliae cortex’s key active phytonutrients were further analyzed for molecular docking with the top ten anti-COVID-19 core targets, including AKT1, TNF, HSP90AA1, IL-6, mTOR, EGFR, CASP3, HIF1A, MAPK3, and MAPK1. This evidence concerns the gene MAPK1 and COVID-19.