The top ten anti-COVID-19 core targets, AKT1, TNF, HSP90AA1, IL-6, mTOR, EGFR, CASP3, HIF1A, MAPK3, and MAPK1, were chosen for molecular docking studies with the Meliae cortex’s key active phytonutrients determined in section 3.7. The gene discussed is CASP3; the disease is COVID-19.