The enrichment analysis revealed that anti-COVID-19 targets of the Meliae cortex might be involved in pathways in cancer, lipid and atherosclerosis, Coronavirus disease – COVID-19, human cytomegalovirus infection, PI3K-Akt signaling pathway, HIF-1 signaling pathway, IL-17 signaling pathway, TNF signaling pathways, EGFR tyrosine kinase inhibitor resistance, etc. These pathways may all make a substantial contribution to the molecular mechanism of the Meliae cortex in treating COVID-19. Here, TNF is linked to COVID-19.