The top 10 of 41 potential anti-COVID-19 core targets (AKT1, TNF, HSP90AA1, IL-6, mTOR, EGFR, CASP3, HIF1A, MAPK3, and MAPK1) were identified as molecular targets of key active phytonutrients of the Meliae cortex that might be implicated in ameliorating COVID-19. This evidence concerns the gene MAPK3 and COVID-19.