GO enrichment analysis shows that anti-COVID-19 effects of Meliae cortex’s key active phytonutrients might be attributed to multiple gene targets that are associated with multiple BP such as protein phosphorylation, peptidyl-serine phosphorylation, inflammatory response, apoptotic process, positive regulation of gene expression, negative regulation of gene expression, positive regulation of protein kinase B signaling, etc. Reports demonstrate that the SARS-CoV-2 infection stimulates host kinases, causing high phosphorylation in the host and virus. This evidence concerns the gene AKT1 and COVID-19.