Among them, pathways in cancer, human cytomegalovirus infection, HIF-1 signaling pathway, and PI3K-Akt signaling pathway are the core pathways followed by nine of ten anti-COVID-19 core targets (HIF1A, EGFR, CASP3, AKT1, MAPK1, MAPK3, HSP90AA1, mTOR, and IL-6), eight out of ten anti-COVID-19 core targets (TNF, EGFR, CASP3, AKT1, MAPK1, MAPK3, mTOR, and IL-6), 7 of ten anti-COVID-19 core targets (HIF1A, EGFR, mTOR, IL-6, AKT1, MAPK1, and MAPK3), and 7 of ten anti-COVID-19 core targets (EGFR, AKT1, MAPK1, MAPK3, HSP90AA1, mTOR, and IL-6), respectively. This evidence concerns the gene PIK3CB and COVID-19.