CD79A and sexuality: Given the role of the IgA isotype against viruses on the mucosal surface where FcαRI/CD89 is specifically expressed (40), we hypothesise that such tandem Fcα-Fcγ chimeric Ab (IgA with a fused Fcγ, Figure 4F) would be effective in the prevention of infectious pathogens such as sexually transmitted HIV-1 (130).