The immunoprotective mechanism of ginsenoside Rg1 can be described as follows: ginsenoside Rg1 inhibits the mRNA expression of ARG2, MMP1, S100A4, and RAPSN and elevates the mRNA expression of LAMC2, DSC2, KRT6A, and FOSB, which enhance the CKA of granulocytes (which was inhibited by NA) and inhibit the development of cancer. This evidence concerns the gene DSC2 and cancer.