These results indicated that ginsenoside Rg1 significantly inhibited the mRNA expression of ARG2, MMP1, S100A4, and RAPSN in granulocytes inhibited by NA and, simultaneously, significantly elevated the mRNA expression of LAMC2, DSC2, KRT6A, and FOSB. These changes could enhance the anti-cancer function of granulocytes and inhibit cancer cell development and progression. This evidence concerns the gene S100A4 and cancer.