Previous research reported that the high expression of ARG2 was related to immunosuppressive microenvironments (45, 46); The high expression of MMPs was associated with N2 tumor-associated neutrophils (47); and the overexpression of S100A4 would promote the metastasis, invasion, and angiogenesis of cancer cells, which are related to poor prognosis in patients with cancer (48–50). Here, S100A4 is linked to neoplasm.