Here, we found that combined Yijinjing and resistance training for 6-months significantly reduced the protein expressions of NLRP3 inflammasome components including NLRP3, caspase-1 and IL-1β in PBMCs as well as the serum IL-1β concentration, indicating that the combined Yijinjing and resistance training were effective in relieving the robust inflammatory responses in pre-diabetes. This evidence concerns the gene CASP1 and diabetes mellitus.