INS and obesity due to melanocortin 4 receptor deficiency: Indeed, previous study have demonstrated that the reduction of NLRP3 expression in adipose tissue was correlated with improved insulin sensitivity in obese T2DM patients, and they further confirmed that ablation of NLRP3 in mice prevented the obesity-induced inflammasome activation in fat depots and liver together with enhanced insulin signaling, suggesting that exercise may improve insulin sensitivity by inhibiting NLRP3 inflammasome activation, thus alleviating diabetes (11).