Maternally expressed gene 3 (MEG3) expression was downregulated, and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and nuclear enriched abundant transcript 1 (NEAT1) expression were upregulated in the synovial fluid, plasma, and PBMCs of RA patients, and MEG3 and NEAT1 with TJC, NEAT1 with SJC, and DAS28-CRP showed significant correlations, suggesting that they might be used as biomarkers to monitor disease activity (159). This evidence concerns the gene NEAT1 and rheumatoid arthritis.