The levels of miR-548a-3p in serum exosomes and PBMCs of RA patients are significantly downregulated and negatively correlated with the levels of RF, ESR, and CRP, suggesting that the miR-548a-3p/TLR4/NF-κB axis could be used as a biomarker for RA diagnosis and targets for therapy (113). This evidence concerns the gene NFKB1 and rheumatoid arthritis.