An analysis showed that mRNA expression of the inflammasome genes NOD-like receptor family pyrin domain containing 3 (NLRP3) and caspase recruitment domain-containing protein 8 (CARD8) in the PBMCs of 230 RA patients from two different populations was correlated with susceptibility and RA progression (p = 0.044) and with severity (p = 0.03), respectively; in addition, the NLRP3 expression levels were also significantly elevated (71). Here, NLRP3 is linked to rheumatoid arthritis.