NFKB1 and rheumatoid arthritis: In addition, patients carrying the LINC00305 AT and TT genotypes (rs2850711 polymorphism) had significantly increased DAS28 scores and LINC00305, NF-κB, and MMP-3 levels, suggesting that LINC00305 and its variant rs2850711 (A/T) might serve as biomarkers for the diagnosis and management of RA (148).