One study comprising 74 RA patients found that YTHDF2 mRNA expression was significantly decreased in RA PBMCs and negatively associated with IL-1β, CRP, ESR, white blood cell counts (WBC), neutrophil counts (N), N%, and NLR values but was correlated with RF and the treatment response (80). This evidence concerns the gene YTHDF2 and rheumatoid arthritis.