The expression of miR-146a was found to be significantly elevated in the peripheral blood of RA patients (n = 76) and positively correlated with RA severity, retinoic acid-related orphan receptor variant 2 (RORc), IL-17 levels, and the Th17 cell ratio, yet significantly negatively associated with the Treg cell ratio, TGF-β1, and forkhead box protein 3 (FOXP3) levels, suggesting that it may serve as a biomarker for disease progression and prognosis in RA patients (102). Here, RORC is linked to rheumatoid arthritis.