Data show that LncRNA H19 encapsulated into exosomes and unambiguously facilitated by hnRNPA2B1 is moved to non-resistant NSCLC cells, resulting in non-responsiveness to Gefitinib (36).In our study, we explored and summarized the direct regulation of lung cancer by lncRNAs and further investigated the indirect regulation of lncRNAs on lung cancer by regulating MDSCs (Figure 2). The gene discussed is HNRNPA2B1; the disease is lung cancer.