IL6 and COVID-19: In contrast, the data from the international CytoSorb registry suggests that serum IL-6 concentrations can be reduced from a median of 5000 pg/mL down to 289 pg/mL after 24 h of cytokine adsorption in severe patients, suggesting that COVID-19 patients with higher levels of cytokines might benefit more from cytokine hemoadsorption with the Cytosorb treatment (41, 92).