In a case series study enrolling 6 COVID-19 patients who were characterized by severe acute respiratory failure with poor response to the prone position (PaO2/FiO2 [arterial oxygen pressure (PaO2), inspired fraction of oxygen (FiO2)] ratio remained <150 after the prone position) and hyperinflammatory state (IL-6 > 1,000 pg/ml and increased levels of ferritin and D-dimer), cytokine hemoadsorption with the CytoSorb adsorber was used as an effective and safe rescue therapy. The gene discussed is IL6; the disease is COVID-19.