Some of the possible mechanisms that explain the effect of exercise on inflammation include (1) stimulating the accumulation of anti-inflammatory cytokines (IL-10 and IL-1 receptor antagonist), (2) alterations of psychosocial factors (depression, stress, and anxiety) (3) adrenergic receptors expressed on several tissues (leukocytes, adipose tissue, and muscle), and (4) weight loss and reducing visceral fat [33, 38]. This evidence concerns the gene IL10 and major depressive disorder.