Targets such as Cep170b, Cacan1e, Camk2b, Clasp2, Ppfia4, and Smarca4 are all known to alter synaptic assemblies and plasticity, are associated with calcium channelopathies and modulation of acetylcholine and other receptors, and are associated with disease states defined by aberrant neuronal firing, such as epilepsy (Basu et al., 2014; Nicole and Pacary 2020; Kessi et al., 2021; Li et al., 2021). This evidence concerns the gene CAMK2B and epilepsy.