KDM1A and cancer: In LSD1-overexpressing, low differentiated HGC-27 and MGC-803 human gastric cancer cell lines, 21 exhibited significant reduction of proliferation (IC50 values = 1.13 and 0.89 μM, respectively), without toxicity against GES-1 and SGC-7901 non-cancer gastric cell lines (IC50 values around 50 μM).