Afterwards, it has been shown that LSD1 regulates angiogenesis, cell cycle arrest, chromatin remodeling and proliferation of cancer cells by demethylation of HIF-1α (Lee et al., 2017), E2F1 (Kontaki and Talianidis, 2010), DNMT1 (Wang et al., 2009), and STAT3 (Yang et al., 2010). The gene discussed is KDM1A; the disease is cancer.