In further studies, CBB1003 displayed weak cell growth inhibition (IC50 = 250 μM) in colorectal cancer (CRC) through downregulation of leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a CRC stem cell marker involved in carcinogenesis (Hsu et al., 2015). This evidence concerns the gene LGR5 and colorectal carcinoma.