KDM1A and acute promyelocytic leukemia: The replacement of the TCP benzene ring with pyrrole and indole moieties afforded MC3288 (8) and MC3382 (9) (Figure 4), which showed significant LSD1 inhibitory activity (IC50 = 0.032 μM and IC50 = 0.040 μM, respectively) and antiproliferative effects at low micromolar level against AML and APL cells (Rodriguez et al., 2015).