In fibrotic cardiac tissue, S100A4 is mainly expressed by hematopoietic cells and endothelial cells (Kong, Christia, Saxena, Su and Frangogiannis, 2013), while S100A4 secreted by subpopulation of macrophage activates hepatic stellate cells during liver fibrosis (Osterreicher et al., 2011; Chen et al., 2015). The gene discussed is S100A4; the disease is Hepatic fibrosis.