PRMT1 and diabetic kidney disease: In another report, high, lipid-induced PRMT1 expression was also demonstrated to mediate apoptosis in mesangial cells via the PERK and ATF6 pathways (Park et al., 2017), and inhibition of PRMT1 expression can delay the progression of diabetic nephropathy by suppressing the AGE-RAGE-mediated rise in ADMA (Leiper, 2005).