Long-term hypertension is also linked to persistent renal injury and chronic kidney disease (Whelton et al., 2017), Upregulation of PRMT1 and PRMT3 in the kidney, as well as downregulation of DDAH expression, were shown to be associated with an increase in ADMA in the rat 5/6 nephrectomy model, exacerbating chronic kidney injury by damage to vascular endothelium (Matsuguma et al., 2006). The gene discussed is PRMT1; the disease is chronic kidney disease.