ATF6 and renal fibrosis: Excessive hyperglycemia can activate protein kinase RNA-like endoplasmic reticulum kinase (PERK) and transcription factor 6 (ATF6) by upregulating H4R3me2a, promoting EMT and ER stress, accelerating PTEC apoptosis, and aggravating renal fibrosis by upregulating PRMT1 expression (Chen et al., 2019).