PRMT1 and chronic kidney disease: Furthermore, PRMT1 expression was elevated in the renal cortex in a 5/6 nephrectomy rat model, which was consistent with overexpression of nNOS and ADMA accumulation; NO synthesis may be affected by nNOS-α and nNOS-β, which may exacerbate renal damage and promote progression of CKD (Tain et al., 2011).