Excessive hyperglycemia can activate protein kinase RNA-like endoplasmic reticulum kinase (PERK) and transcription factor 6 (ATF6) by upregulating H4R3me2a, promoting EMT and ER stress, accelerating PTEC apoptosis, and aggravating renal fibrosis by upregulating PRMT1 expression (Chen et al., 2019). This evidence concerns the gene EIF2AK3 and renal fibrosis.