EGF and dental caries: Up until now, the plant extract has been used to biologically synthesize gold nanoparticles (Anandan and Gurumallesh Prabu, 2018), silver nanoparticles (Sebelemetja et al., 2020) and stabilised polymeric nanoparticles (PLGA-PEG) for the treatment of dental caries (Sebelemetja et al., 2020), but none have reported on loading the extract in a hydrogel embedded with epidermal growth factor (EGF).